الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 66 |  |  |
| | | from | 66 | | |
Abstract
In recent decades, the exploration of the oceans has allowed the discovery of a multitude of previously unknown habitats characterized by extreme conditions. These environments host a variety of organisms adapted to these conditions and produce a wide range of active biomolecules. More than 25,000 new biologically active compounds have been identified in the past fifty years, with an increment of 5% per year and 1378 new molecules identified in 2014 alone. Marine microorganisms, including bacteria, have attracted great attention as potential leading compound producers. Marine microorganisms possess unique metabolic and physiological features with several inspiring bioactive and chemotherapeutic compounds (Corinaldesi et al., 2017).
It has been reported that marine invertebrates harbor a higher population of bacteria able to produce novel bioactive compounds, and many sessile invertebrates build their defensive strategies against predators or competitors on the production of natural compounds, often correlated to associated microbial communities (Rizzo and Giudice, 2018).