الفهرس | Only 14 pages are availabe for public view |
Abstract Hair samples are one of the most important resources in the forensic analysis of crime scenes, often providing valuable information that can lead to the identification of a suspect or a victim. In this study, Thirty Wistar male rats were grouped into three groups and used for HPTLC quantitative evaluation of Cannabis and Pregabalin residues in hair and serum in addition to screening of their toxicological effects. First group kept as negative control, second group (Cannabis group, administered Cannabis by gastric tube at a dose of 3 mg/kg b. wt.) and third group (Pregabalin group, administered Pregabalin by gastric tube at a dose of 30 mg/kg b.wt.) daily for eight weeks. Residues of Cannabis and Pregabalin were evaluated by HPTLC, Oxidative stress parameters were analyzed in serum. Histopathological examination of the kidney, liver and brain samples was done. Results revealed that Cannabis and Pregabalin were both deposited in hair and serum compared with control groups; the toxicological effect was more marked in Cannabis group. Using of hair samples can be added besides blood and urine samples for drug addicts tests. |