الفهرس 
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Abstract
This was a randomized controlled study conducted at Assiut University Hospital. 80 patients who underwent arthroscopic rotator cuff repair (ARCR) under general anesthesia in beach chair position (BCP) were randomly assigned into two matched groups, group L (n= 40) received lidocaine 5 minutes after induction of anesthesia until the end of surgery, whereas, group C (n= 40) received normal saline. In our study we found that: • Postoperative cognitive function was assessed using mini-mental state examination (MMSE) test. Lidocaine provided a neuro-protective effect with more incidence of post-operative cognitive dysfunction (POCD) in group C. • No differences between both groups in intraoperative hemodynamics and SpO2. • There were no significant differences pre-operative and 30 min after extubation in serum lactate levels between the two groups. Serum lactate level at 30 min after extubation was significantly elevated in both groups than the pre-operative value. • Patients in both groups were discharged successfully from hospital three days after surgery. • No differences found regarding intraoperative complication except for hypertension which occurred significantly less in group L. • No patient in both groups experienced postoperative complications.
Conclusion: IV lidocaine is safe, effective and had a neuro-protective effect on early POCD in patients underwent ARCR under general anesthesia in BCP.