الفهرس 
Title : clinical comparison of the effect of non-eugenol containing periodontal pack with and without platelet rich fibrin on post-operative pain and wound healing after surgical gingival depigmentation: a randomized clinical trial
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Abstract
Aim: The aim of the study was to evaluate the effect of platelet rich fibrin on post-operative pain and wound healing after surgical depigmentation
Methodology: Twenty-four patients with gingival pigmentation were recruited and randomly assigned to control group; non-eugenol periodontal pack only, or to test group; L-PRF with periodontal pack. Gingival depigmentation was done using a combination of scalpel and bur techniques and both groups were covered using periodontal pack. Post-operative pain, healing index, epithelization test and pigmentation recurrence were tested and compared. Post-operative pain was measured using visual analogue scale (VAS), wound healing was measured using healing index and epithelization test while pigmentation recurrence was measured using gingival pigmentation index.
Results: In the control group, 100% of the patients reported pain ranging from moderate to distressing pain after the 5th day while in the test group 8.3% reported very mild pain after the 5th day. The healing index results were in favour of the test group with 91.7% of the patients scored 4 (Very good) on the 5th day. While in the control group 83.3% scored 2 (poor) on the 5th day and 16.7% were observed to have a score 3 (Good). The epithelization test was the most significant with 100% received a negative result in the test group after 5 days with 66.7% completely healed and 33.3% partially healed when compared to 100% of the control group having a positive score (no epithelization). The pigmentation recurrence after 6 months was observed in 66.7% in the test group while only 33.3% in the control group.
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Conclusion: Using PRF after gingival depigmentation results in decreased post-operative pain and better wound healing when compared to using periodontal packs alone.