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Abstract has been postulated that reduced hydrogen sulphide produced from respiratory epithelium might be implicated in the pathogenesis of acute asthma. This case -control study investigated serum levels of hydrogen sulphide (H2S) in a group of acute asthmatic children and compared it to a group of healthy matched controls. The case group included 40 Egyptian asthmatic children visiting the Emergency Room. and the age- and sex-compatible control group included 40 healthy children. The study reached the following: Eosinophilic percentage and absolute eosinophilic count were significantly higher in cases compared to controls. There was no statistically significant difference in serum H2S levels between cases and controls. There was significant inverse correlation between serum H2S and respiratory rate (P=0.041). However, there were no significant correlations tween serum H2S and other clinical or laboratory variables. Serum H2S had a sensitivity of 50% and a specificity of 32.5% in discriminating acute asthmatic children from normal controls. The study concluded that serum H2S levels in pediatric acute asthma still need further research. |