الفهرس 
Type 2 Diabetes MellitusOnly 14 pages are availabe for public view
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Abstract
Several studies have shown associations of ADIPOQ polymorphisms
with diabetes mellitus, obesity and cardiovascular diseases; however,
inconsistencies are present with different study populations. The aim of the
present study was to indicate the relation between adiponectin gene
mutation variant +276G/T (rs1501299) and risk of T2DM among Egyptian
obese patients.
This case-control study included totally 100 Case , they were
subdivided into four groups ;group 1 included 25 nondiabetic non obese
cases ,group 2 included 25 diabetic obese cases ,group 3 included 25
nondiabetic obese cases and group 4 included 25 diabetic non obese cases .
They were recruited and assessed for eligibility from the Endocrinology
Outpatient Clinics and Inpatient Ward in Menoufia University Hospital.
The present study revealed a statistically significant increase in
weight and BMI among the diabetic obese group B and the non diabetic
obese group C in comparison with the diabetic non obese group D (P
value=0.001). Moreover, there was a statistically significant increase in
fasting blood glucose, 2h postprandial blood glucose and HbA1C % among
diabetic obese group B and the diabetic non obese group D in comparison
with the non diabetic obese group C (P value=0.001).
The present study revealed statistically significant difference
between the studied groups regarding TSH levels (P value>0.001).
Regarding the liver function test among studied groups, the present
study indicated a statistically significant increase in ALT among nondiabetic
obese group C in comparison with the diabetic obese and the
diabetic non obese groups (P value=0.001).
Summary
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The present study indicated statistically significant difference
between the studied groups regarding blood urea and creatinine levels (P
value 0,001).
The present study indicated a statistically significant increase in
serum cholesterol, HDL, LDL and serum triglycerides among diabetic
obese group B and the non-diabetic obese group C in comparison with the
non-diabetic non obese group A and the diabetic non obese group D (P
value=0.001).
The present study indicated statistically significant difference
between ADIPOQ SNP by real time PCR among studied groups. (P value
0,003).
The present study revealed that the frequency of TT genotype for
rs1501299polymorphism was significantly associated with increased height
(P value=0.013), fasting blood glucose (P value=0.002), 2h postprandial
blood glucose (P value=0.024), TSH (P value=0.001) and creatinine (P
value=0.026) among patients in the diabetic obese group B.
The present results revealed that the frequency of TT genotype for
rs1501299polymorphism was significantly associated with increased
weight (P value=0.005), BMI (P value=0.001) and serum triglycerides (P
value=0.008) among patients in the non-diabetic obese group C.
The present study revealed that the frequency of TT genotype for
rs1501299polymorphism was significantly associated with increased
fasting blood glucose (P value=0.004) among patients in the diabetic non
obese group D.