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Abstract Resting state MRI (rs-MRI) investigation of the human brain progressively acquires a central role in accurate diagnosis of complex psycho-cognitive disorders and pre-procedural planning of neuro-surgical interventions at the expense of task-based MRI studies for pragmatic reasons of independence of patient co-operation, short scan time and providing more comprehensive overview of functional brain connectivity. Moreover, rs-MRI is an idealistic research tool for psycho-cognitive research experiments. In this study, the precision, time effectiveness and reproducibility of the following rs-MRI analysis software were assessed: SPM12, CONN, FSL and produced data were used to create a reference rs-MRI dataset for adult Egyptians population. Few statistical significant differences in test-retest results of the forementioned programs and their time-effectiveness with CONN being the most time-effective software giving it an edge as an rs-MRI software, in addition to its comprehensive image quality check tool that did not exist in the other software in same flexible and thorough manner. |