الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Part I: displays different publications concerning the complexation of hydrazones with a great attention to the compounds similar to that investigated and their biological activities. Part II: covers the experimental part and illustrates the experiments used in this work. It includes a list of reagents, stock solutions along with the physical measurements and instrumentation. The working procedures description for the preparation of the ligand and its metal complexes. In addition, this chapter includes the recommended procedures for Antioxidant activity of the prepared metal complexes.Part III: The proposed chemical formulae of the ligands and their metal complexes are found to be in good agreement with the stoichiometry concluded from their analytical data of carbon, hydrogen, nitrogen, chloride and metal contents. The coordination sites of the ligand, the nature of metal-ligand bonds and the nature of the carbonyl group and the existence of the solvated molecules have been elucidated using IR spectra. Different modes of chelation for the investigated ligands are suggested based on careful comparison between the spectra of the ligands and their corresponding complexes. The data obtained are summarized as:a.HDMTH acts as neutral NS bidentate chelate in, [Mn(HDMTH)Cl2(H2O)2] and [Co(HDMTH)Cl(OH)(EtOH)2], [Ni(HDMTH)2Cl2].2EtOH, [Cd(HDMTH)Cl2(EtOH)H2O] and [VO(HDMTH)(SO4)(H2O)].4EtOH complexes through (C=N)azomethine and S atom of thiophene ring groups, as neutral ONS tridentate chelate in [Hg(HDMTH)Cl(OH)(EtOH)].3EtOH complex, as well as mononegative ON bidentate manner via enolized carbonyl and new azomethine (C=N*-N=C) in [Cr(DMTH)Cl2EtOH(H2O)].2H2O and [Cu(DMTH)Cl(EtOH)(H2O)2] complexes, and neutral N2O2 tetradentate in [Zn(HDMTH)2Cl(OH)] complex, where two ligand moieties coordinating one metal ion via O and N atoms. b.HDMFH ligand shows modes; acts as a neutral ON bidentate chelate via O and N atoms of carbonyl and azomethine groups as in [Cr(HDMFH)(OH)(Cl)2EtOH].H2O, [Mn(HDMFH) Cl2(EtOH)H2O].H2O, Cu(HDMFH)2Cl(OH)].3H2O and [Zn(HDMFH)Cl(EtOH)(OH)H2O]. The second mode is neutral NO through O atom of furan ring and N of azomethine in [Co(HDMFH)Cl(OH)].EtOH, [Hg(HDMFH)Cl2].2EtOH and [VO(HDMFH)(SO4)(H2O)].2EtOH complexes, The ligand acts also as neutral NO bidentate but through oxygen atom of furan ring and the nitrogen of NH as in [Ni(HDMFH)Cl2(EtOH)2].EtOH complex, and HDMFH coordinates as neutral NS bidentate via S atom and N atom of azomethine group in [Cd(HDMFH)Cl(OH)(EtOH)H2O].EtOH complex . It was impossible to isolate a single crystal of any complex owing to its distorted octahedral arrangement, so x-ray powder diffraction analysis had been applied on some complexes. In order to assess the influence of the structural properties of the ligands and the type of the metal on thermal behavior of the complexes, the order (n) and the heat of activation (Ea) of the various decomposition stages are determined from the TGA and DTGA. This section includes also the determination of the thermodynamic parameters of activation (ΔH*, ΔS* and ΔG*). Finally, Antioxidant activity using ABTS+ assay, erythrocytes antihemolysis assay and breast cancer for HDMTH, HDMFH and their metal complexes was included.