الفهرس 
Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Heterodiazole and Related Fused Ring Derivatives as Potential Antitumor Agents
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Abstract
This article-based thesis comprises five chapters in addition to English and Arabic
summaries;
The first chapter is a general introduction to cancer and its treatment
strategies.
The second chapter is a review article titled “Comparative Study of the
Synthetic Approaches and Biological Activities of the Bioisosteres of 1,3,4-
Oxadiazoles and 1,3,4-Thiadiazoles over the Past Decade”.
The third chapter presents an original article entitled “New 5-Aryl-1,3,4-
Thiadiazole-Based Anticancer Agents: Design, Synthesis, In Vitro Biological
Evaluation and In Vivo Radioactive Tracing Studies”.
The fourth chapter includes an original article titled “Elaborating 5-(4-
chlorophenyl)-1,3,4-thiadiazole scaffold with a p-tolyl sulfonamide moiety
enhances cytotoxic activity: Design, synthesis, in vitro cytotoxicity evaluation,
radiolabelling, and in vivo pharmacokinetic study”.
The fifth chapter consists of an original article entitled “Newly synthesized
series of oxoindole–oxadiazole conjugates as potential anti-SARS-CoV-2 agents:
in silico and in vitro studies”.