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Abstract COVID-19 infection is associated with serious maternal and fetal outcomes on pregnancy. Negative effects of COVID-19 should not be ignored in first trimester pregnancies, for which fewer studies have been conducted, compared to other trimesters. Objectives: To assess maternal and fetal outcome in women with COVID-19 infection. Methods: This study included 80 pregnant females infected with COVID-19 in the first trimester. Results The most common presenting symptoms among the included cases were fever in 40 cases (50%), cough in 46 cases (57.5%), sore throt in 49 cases (61.3%) and dyspnea in 42 cases (52.5%). The main pregnancy associated complications were bleeding in 24 cases (30%), abortion in 20 cases (25%), Hyperemesis gravidarum in 1 case (1.3%), hospital admission in 3 cases (3.8%), Hypertension/ preeclampsia in 10 cases (12.5%), gestational DM in 1 case (1.3%) and PPROM in 16 cases (20%). Regarding the mode of delivery, 43 pregnant females (53.8%) had normal vaginal delivery while the incidence of caesarean delivery was 46.3%. Postpartum haemorrhage occurred in 1 case (1.3%) and 2 cases were admitted into ICU (2.5%). The neonatal complications included congenital anomalies in 1 case (1.7%), IUFD in 3 cases (5%), NICU in 12 cases (20%) and fetal morbidity in 8 cases (13.3%). Conclusion COVID-19 infection is associated with serious maternal and fetal outcomes on pregnancy. Negative effects of COVID-19 should not be ignored in first trimester pregnancies, for which fewer studies have been conducted, compared to other trimesters. The incidence of maternal complications was relatively higher as compared to the neonatal and fetal complications |