الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Acne vulgaris is a common chronic skin inflammatory disorder of the pilosebaceous unit and primarily affects the face, back, and chest, which have a high concentration of sebaceous glands. In order to prevent post-acne scarring and the detrimental psychosocial deficits that follow, early identification and treatment of acne vulgaris are crucial.
Survivin is an apoptosis inhibitor protein that regulates cell division, proliferation and survival. It has been found that survivin increases in keratinocyte proliferative and inflammatory states, which are strongly involved in the pathogenesis of the acne lesions.
This case control study was conducted on sixty participants; twenty had active acne, twenty with recent post inflammatory acne scar and twenty age and sex matched healthy controls. Serum survivin level were measured in the three studied groups, the active acne group were additionally subjected to follow up survivin level assessment after a 3-month course of oral isotretinoin therapy.
This study showed that there was a statistically significant difference in survivin serum level among the three studied groups showing the highest levels in scar group followed by active acne group then control. Additionally, there was a statistically significant difference in survivin level among active acne group before and after three months of oral isotretinoin therapy. Survivin levels were significantly decreased after isotretinoin treatment. Additionally, there was a statistically significant positive correlation between the reduction in survivin level and clinical improvement in active acne group after isotretinoin treatment.
This study also showed that the longer the duration of the disease the higher the survivin level. Moreover, there was a statistically significant relation between the severity of the disease and the level of survivin among the studied groups. Therefore, we believe that survivin is an important serological marker in prediction of the course and severity of acne and acne scarring.