الفهرس 
Introduction and Aim of WorkOnly 14 pages are availabe for public view
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Abstract
Diabetes and renal stone are a syndrome of disordered metabolism, usually due to a combination of hereditary and environmental causes, resulting in abnormally high blood levels (hyperglycemia) that may complicate to stone formation. Blood glucose levels are controlled by a complex interaction of multiple chemicals and hormones in the body, including the hormone insulin made in the beta cells of the pancreas. Diabetes mellitus refers to the group of disease that lead to high blood glucose levels due to defects in either insulin action in the body. Renal stone is one of risk factors of diabetes that caused by some physiological and biochemical changes occurred by diabetes mellitus.
In rodent models, induction of diabetes and renal stone caused by alloxan and ethylene glycol, respectively. Alloxan is genotoxic agent that is targeted to the β-cells, is used to trigger the initial cell death. High single doses of alloxan cause releasing of more free radicals that cause extensive β-cell necrosis and damage leading to diabetogenic disease. Ethylene glycol was used to produce hyperoxaluria and consequently the deposition the calcium oxalate crystals in rat kidneys. Also, Ethylene Glycol disturbs oxalate metabolism by way of
increase the substrate availability that increase the activity of oxalate synthesizing enzymes in the rats.
The present study is designed to investigate the biochemical risk factors of kidney stone in diabetes, animal model of ethylene glycol induced hyperoxaluria, animal model of alloxan induced hyperglycemia on rats, physiological interaction between hyperoxaluria and diabetes mellitus and the physiological & histopathological effect of green tea application on kidney function parameters, liver function parameters, redox state, parathyroid hormone and ionic assay against hyperoxaluria and hyperglycemia in animals model.