الفهرس 
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Abstract
ABSTRACT
Di-n-butyl phthalate (DBP), a ubiquitous environmental contaminant, is widely used as a plasticizer in many industrial products and directly involved in numerous health issues. Naringin (NG) is a dietary flavonoid that possesses numerous health benefits. Therefore, this study aimed to evaluate the prospective ameliorative potential of NG against the hepatorenal and testicular damages induced by DBP in male rats. Rats were assigned into six equal groups, and treated orally, 3 times a week for 8 consecutive weeks. Control vehicle group was administrated olive oil, naringin-treated group was administered NG (80 mg/kg), DBP 250- and DBP 500- intoxicated groups received DBP (250 mg/kg) and (500 mg/kg), respectively, NG+DBP 250 and NG+DBP 500 groups received NG, an hour prior to DBP 250 and 500 administration. DBP evoked dose- and time- dependent elevations in the serum ALT and AST activities, and urea, creatinine and MDA levels, accompanied by significant reduction in the serum TAC. Moreover, significant decreases in the sperm count, viability, and total motility, serum testosterone level, testicular GSH content and CAT activity concomitantly with a significant increase of the testicular MDA level after 8 weeks of exposure. Furthermore, DBP induced various degrees of pathological findings, including mitotic changes and hydropic degeneration in hepatocytes, decrease in the size of the glomerular tuft, and increase in the size of Bowman’s space of the kidney, absence of spermatozoa, degenerative changes of the epithelial lining of seminiferous tubules and a significant decrease in the thickness of the seminiferous tubules’ epithelium. Contrariwise, concurrent treatment with NG substantially attenuated the hepatorenal and testicular toxic effects of DBP, evidenced by the notable improvements of the serum and tissue biomarkers, sperm quality and histological architectures of liver, kidney and testis. In conclusion, the findings recorded herein proved that NG could mitigate DBP-induced hepatorenal and testicular damages and impairment of spermatogenesis, mainly via its potent antioxidant activity.
Keywards: Di-n-butyl phthalate, Naringin, Oxidative stress, Hepato-renal toxicity, Testis.