الفهرس 
CHRONIC SPONTANOUS URTICARIAOnly 14 pages are availabe for public view
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Abstract
ABSTRACT
Background: chronic spontaneous urticaria (CSU) is estimated at approximately 15–25% of the population, affecting the quality of patients’ life. Parasitic infections are considered one of the causes of CSU, which are still under study. Tissue and liver parasites such as Toxocara and Fasciola are paid insufficient attention in diagnosis.
Objective: To evaluate the prevalence of parasitic infections, especially tissue and liver parasites (Toxocara and Fasciola), in adult patients with chronic spontaneous urticaria compared to healthy controls.
Subjects and Methods: This case-control study was conducted on 100 Egyptian adult Patients having chronic spontaneous urticaria according to the EAACI/GALEN/EDF criteria recruited from the allergy and immunology outpatient clinic and inpatient department at Ain Shams University Hospitals from 2020 and 2022. Also, 100 healthy controls who were group-matched with patients for age and sex recruited from relatives of patients, hospital workers, and nursing staff were included in this study. Direct stool examination and staining with Modified Zeihl Neelsen stain were done to exclude parasitic infection. Also, ELISA test for the detection of Fasciola and Toxocara IgG was done for all cases and control in this study.
Results: Parasitic infections were detected in (20%) of patients with CSU compared to control group (8%) with the predominance of Blastocystis hominis. The seroprevalence of Toxocara species and Fasciola species among 100 patients with CSU compared to the control group was (23%, 4%) for Toxocara and (5.0%, 2%) for Fasciola.
Conclusion: Our results highlighted an association between parasitic infections and CSU. Accordingly, adult patients complaining of CSU should be screened by stool analysis. Also, tissue parasites such as Toxocara should be investigated by serological tests for the detection of antibodies