الفهرس 
Title : Clinico- pathological study of Dermato-fibrosarcoma protuberans five years experience in National Cancer Institute, Cairo University
ContentsOnly 14 pages are availabe for public view
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Abstract
ermatofibrosarcoma protuberans (DFSP) is a cutaneous fibro-histiocytic, intermediate-grade, locally-aggressive tumor which only rarely metastases. DFSP recurs commonly but metastasizes very rarely (less than 1% of cases). Fibrosarcomatous DFSP is more aggressive progressive form of DFSP with a higher rate of metastasis which is classified as a G2 tumor.(Stojadinovic et al., 2000)
This current study was done to evaluate the clinico-pathological factors and the surgical factors that affect the local recurrence and disease free survival for Dermato-fibrosarcoma protuberans cases at the National cancer institute.
This retrospective study included 37 patients with dermatofibrosarcoma protuberans presented to Surgical Oncology Department at National cancer institute (NCI), Cairo University (CU), between January 2010 to December 2014. Patient files were retrieved from Biostatistics & Cancer Epidemiology Department and Pathology Department of National Cancer Institute of Cairo University. Patients` demographic, clinical and treatment data were analysed using SPSS 23..
The results showed that: Seventeen female patients (45.9%) and 20 male patients (54.1%) were included. Their age ranged from 6 years to 65 years, with a mean of 36.5 ± 14.4 years. The dermatofibrosarcoma protuberans were presented mostly on patients’ thigh (22.9%) and back (20.0%), followed by the abdominal wall (14.3%), scalp (8.6%), shoulder (5.7%) and leg (5.7%). The least diameter of dermatofibrosarcoma protuberans ranged from 0.5 to 5.5 cm while its largest diameter ranged from 0.5 to 14 cm. The local recurrence of dermatofibrosarcoma protuberans occurred in 30.6% of all patients for the first time, while it occurred in 13.9% and 5.6% for the second and third times, respectively. local recurrence of dermatofibrosarcoma protuberans did not show significant associations with patients’ age or sex, and tumor’s site or size. However, local recurrence tended to occur among older age and female patients. Also, lesions at the upper limb and abdominal wall had more local recurrence rates. the survival time of patients with dermatofibrosarcoma protuberans. The median survival time was 4 years while the mean survival time was 4.11 years. The majority of studied patients survived for 3 or 4 years (43.2% or 35.1%, respectively). Survival time of dermatofibrosarcoma protuberans did not show significant associations with patients’ age or sex, and tumor’s site or size. However, female patients survived less than males. Also, survival time was inversely correlated with patients’ age and with tumor size. Patients with tumor lesions on their back or chest wall survived less than patients with other tumor sites. Close margin is a very clear highly significant factor for the recurrence of Dermatofibrosarcoma