الفهرس 
Primary Open Angle GlaucomaOnly 14 pages are availabe for public view
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Abstract
Purpose: To evaluate both macular and optic nerve head vessel perfusion
density in normal eyes as a control group, in mild open angle glaucoma patients and
in moderate to severe open angle glaucoma patients regardless of IOP level.
Methods: A case controlled study conducted, Total 80 eyes of 46 participants
were included: 60 eyes of 36 open angle glaucoma patients, and 20 eyes of 10 healthy
participants. Patients underwent 3.0 × 3.0 mm optical coherence tomography
angiography scans centered on the macula were obtained and 4.5×4.5 on the optic
disc.
Results: OCTA scans for both glaucomatous and healthy eyes demonstrated
diminished microvasculature in the peripapillary retina which is not found in control
group. RNFL thickness and whole image VD of the optic nerve head both were
perform equally for identifying glaucoma patients from healthy individuals (p value
<0.001) . Whole disc VD was significantly lower in all glaucomatous eyes being the
second most important parameter in glaucoma diagnosis, it was 38.02±8.74, while
it was 50.41±2.58 in control group (P value <0.001). Thus, glaucoma and healthy
eyes may be distinguished with great ease using peripapillary VD and whole image
VD. The severity of glaucoma is correlated with a decline in macular VD percent,
the reduction of superficial VD, it was 36.09± 5.67in glaucoma groups, while it was
46.64± 5.53in control group (P value <0.001), which is more than that of deep layer
(P value <0.008).
We found in this study that there is no difference between superior and inferior
hemispheric affection in glaucoma cases that is statistically significant.
There is no significant difference in the FAZ size between the control group
and glaucoma groups at any stage (P value: 0.999).
Conclusion: OCT A can offer details that support VF and OCT tests for
monitoring early glaucoma diagnosis, glaucoma progression detection, and risk
Abstract
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assessment. Peripapillary VD varied considerably between the healthy and
glaucoma groups as well as the mild and moderate to severe glaucoma subgroups,
which has aided in understanding some elements of the vascular damage identified
in POAG. This conclude that peripapillary VD measurement is helpful in
differentiating the various stages of glaucoma severity.
Keywords: Glaucoma; Optical coherence tomography angiography, Vessel
density, Peripapillary vessel density, Foveal avascular zone.