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العنوان
Analyzing fetal cardiac remodelling in pre-eclamptic patients/
المؤلف
Okda, Hagar Gamal Abdel Moniem Abdel Hamid .
هيئة الاعداد
باحث / هاجر جمال عبد المنعم عبد الحميد عقدة
مناقش / السيد البدوي عوض
مشرف / حسام إبراهيم عزب
مشرف / هشام حسني الجمال
الموضوع
Obstetrics. Gynecology.
تاريخ النشر
2023.
عدد الصفحات
64 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الطب
تاريخ الإجازة
31/5/2023
مكان الإجازة
جامعة الاسكندريه - كلية الطب - Obstetrics and Gynecology
الفهرس
Only 14 pages are availabe for public view

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Abstract

Preeclampsia is a prevalent pregnancy-related medical condition, which is a leading cause of maternal and perinatal complications.
The fetal-placental unit may exhibit manifestations of preeclampsia secondary to decreased uteroplacental blood flow.
Through increasing the fetal cardiac afterload, increased placental vascular resistance may have an impact on fetal cardiac function.
The aim of this work was to assess fetal cardiac remodelling of non growth retarded fetuses in pregnancies complicated with mild and severe preeclampsia
150 pregnant females were included in the study and were divided into 3 groups where group I included 40 mild preeclamptic pregnant women, group II included 35 severe preeclamptic pregnant women and group III included 75 non preeclamptic pregnant women which was divided into group IIIa and group IIIb with matching gestational age to group I and group II.
Assessment of the fetal cardiac function included assessment of cardiac morphology through measurement of ventricular and atrial diameters, sphericity index, cardiothoracic ratio, mitral valve annulus, aortic valve annulus, tricuspid valve annuus, pulmonary valve annulus, interventricular septum diameter at systole and diastole in mm and left ventricle posterior wall diameter at systole and diastole.
As for the cardiac systolic functions, measurement of the ejection fraction, mitral annular plane systolic excursion, tricuspid annular plane systolic excursion and peak systolic velocity by tissue doppler was done.
As for the diastolic function, assessment of the right and left ventricular early and late peak flow velocity waves utilizing pulsed wave doppler and assessment of e’ and a’ waves using tissue doppler was done.
While for the left ventricular global function, myocardial performance index and cardiac output were measured.
Our study showed that fetuses of mothers with preeclampsia had higher sphericity index but lower atrial and ventricular diameter length.
The study also showed lower fetal MAPSE and TAPSE values for cases with preeclampsia but the difference from the control group was only significant regarding right ventricle.
Furthermore, there was also difference in the tissue doppler study as shown in the form of higher fetal mitral valve S wave and decreased E/e’ ratio for both mitral and tricuspid valve in cases with severe preeclampsia.
Moreover, fetuses of mothers with preeclampsia showed increased myocardial performance index, increased cardiac output and lower ejection fraction but the difference between study groups regarding cardiac output and ejection fraction was not statistically significant.