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Abstract Spontaneous bacterial peritonitis (SBP) is the most common infective complication of liver cirrhosis, which is mainly due to Gram-negative bacteria (Pericleous, Sarnowski et al., 2016). Its incidence ranges from 10% to 30%in hospitalized patients, with a mortality as high as 46% (Pericleous, Sarnowski et al., 2016)(Gentile, Buonomo et al., 2017). The cornerstone of the diagnosis of SBP is a polymorph nuclear neutrophil (PMN) count in ascitic fluid exceeding 250 cells/microL. However, it has been suggested that specific molecules in ascitic fluid, namely, C-reactive protein, lactoferrin and calprotectin, may be additional prognostic or diagnostic tools in patients with SBP ( Runyon, 2013 )(Kadam, Acharya et al., 2016).Among its various biological activities, 25- the first catabolite of vitamin D — is involved in the immune response. Low levels of circulating 25-OH vitamin D are associated with infections in patients with cirrhosis (Anty, Tonohouan et al., 2014). Serum 25-OH vitamin D levels are generally lower in these patients than in controls (Putz-Bankuti, Pilz et al., 2012) and even lower in patients with decompensated cirrhosis (Singh, Taneja et al., 2022). |