الفهرس Only 14 pages are availabe for public view
 |  | from | 196 |  |  |
| | | from | 196 | | |
Abstract
Background and aim: The incidence of type 2 diabetes mellitus has risen to epidemic proportions. The pathophysiology of Type 2DM is complex and involves insulin resistance, pancreatic B-cell dysfunction and visceral adiposity. It has been known for decades that a disruption of biological rhythms increases the risk of developing obesity. Resetting of the circadian rhythm could play an important role for adjustment of the disturbed metabolism observed in Type 2DM and metabolic syndrome. Objectives: This experimental study was designed to investigate the potential role of bromocriptine the well known D2 agonist, on regulation of metabolic disorders observed in Type 2DM induced in rats by fructose enriched diet. Metformin was used as a standard drug for comparison. Results: normal rats that received bromocriptine or its vehicle showed insignificant changes of all measured parameters except for SOD, AST and ALT which showed a significant elevation in bromocriptine group. Hypotension was also observed in the previous group. Diabetic untreated group showed hyperglycemia, hyperinsulinemia, elevation of hemoglobin A1C, HOMA IR score, cholesterol, triglycerides, IL 6, AST and ALT serum levels , decrease in SOD serum level. In addition they induced hypertension. Treatment with either bromocriptine or metfomin or their combination decreased the elevated levels of these parameters, improved the decreased levels of SOD & lowered the elevated BP. Moreover, the tested drugs ameliorated the histopathological changes observed in cardiac and liver tissues isolated from diabetic rats. They also improved the response of isolated aortic contractions by PE& AgЇЇ