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Abstract
The aim of the present study was to investigate the effect of laser therapy on histological changes of thoracic aorta in hypertensive rats.Results: there were significant increase in systolic blood pressure in expermintal induction L-NAME for 1 month and hypertensive untreated sub group in comparison with (normal) control group , on the other hand there were significant decrease in systolic blood pressure in treated group after 1.5 month in comparsion with normal group, and also there were significant decrease in systolic blood pressure after 3 month in comprsion with hypertensive untreated group , and there were also significant decrease in diastolic blood pressure in treated hypertensive group after three months in comparsion with hypertensive untreated group.Microscopic examination of the heart of experimental rats induction of hypertension after daily oral administration of L- NAME (5 mg/rat) for 1 month showed a separation of muscle fibers associated with intracardial congestion and hemorrhage, on the other hand rates treated with laser for 1.5 month showed regeneration of the cardiac muscle and intracardial congestion and hemorrhage, and after 3 months showed regeneration of the cardiac muscle. While, microscopic examination of the aorta of experimental rats induction of hypertension showed irregularity in the structure of the elastic fibrils in the tunica media, and also deterioration in the formation of elastic lamellae, Histopathological of aorta treated with laser for 1.5 showed progression of aorta intima and endothelial structure are attenuated , the other group treated with laser for 3 months showed intima with little endothelial cell drop, and media smooth muscle cells proliferated with uniform thickness and regular arrangement. In conclusion: Laser therapy has beneficial effect on hypertension as indicated by the changes in systolic and diastolic blood pressure and the histological changes of thoracic aorta