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Abstract
Objectives: to find out if HGF level relates to the degree of heart failure and cardiac parameters estimated by echocardiography in hemodialysis patients with congestive heart failure , and to detect the prognostic value of HGF to predict mortality in such patients within 6 months of follow up Methods: We studied the level of hepatocyte growth factor in 41 patients on dialysis with congestive heart failure(group I) compared to other groups of heart failure patients with variable degrees of renal functions (II+III), dialysis patients without heart failure (IV) and group of normal control subjects (V) .Any patient with viral hepatitis (B or C) or on heparin were excluded. Left ventricular ejection fraction assessed by echocardiography .We followed up patients for 6 months to detect mortality Results: There is significant difference in HGF levels in group I patients with mild impairment of systolic function compared to group I patients with moderate impairment of systolic function (p-value =0.002) .There is significant difference in HGF levels between group I patients with moderate impairment of systolic function compared to group II+III patients with moderate impairment of systolic function (p-value= 0.003) There is no significant difference in HGF levels in patients who survived compared to those who died in neither group I patients nor group II +III patients Conclusion: According to these results HGF can be considered as a marker for assessment of severity of impaired LVEF in patients with congestive heart failure on dialysis, However it cannot be used to predict short term mortality