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Abstract
This single-blind randomized clinical trial was conducted to assess effect of 4% articaine infiltration versus 2%lidocaine nerve block after premedication by ibuprofen on anesthetic efficacy in endodontic treatment of first permanent molar with acute irreversible pulpitis. Methods: Fifty-two patients actively experienced pain and accepted to participate in this single-blinded study and underwent single visit endodontic treatment. All patients were equally distributed in control and experimental group. Every patient received 4% artiacine as buccal infiltration or 2% lidocaine as inferior alveolar nerve block (IANB) after one hour from receiving ibuprofen 600mg as premedication according to his group. Endodontic access was initiated after 10 minutes of anesthesia, lip numbness and EPT reading. Pain during endodontic access cavity preparation and cleaning and shaping was recorded by VAS and patient received intra-pulpal anesthesia of the same anesthetic solution as supplemental. Postoperative pain was evaluated at 6,12 and 24 hours after endodontic treatment. The number of analgesic tablets would be recorded (if taken). Statistical analysis was done by Chi square test was used for categorical data and Mann Whitney U test was used to compare VAS scores between groups