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Abstract
Warts are benign lesions caused by human papilloma virus (HPV). Host defense against HPV relies on intact and functioning cellular immunity including T cell and natural killer (NK) cell cytotoxicity. Therefore, in patients in whom warts are severe, concern for immune defects is raised. HVEM (herpes virus entry mediator) is a member of the tumour-necrosis factor receptor family. It has diverse functions, augmenting or inhibiting the immune response. It acts as a receptor to enhance immune responses through binding LIGHT or LTalpha which signaling is important for cell survival, inflammation, and tumor eradication. {uF0A7}Aim of work: To identify the role of cell-mediated immunity, expressed as HVEM level, in cases of multiple/recurrent verrucae, in order to assess its role in the adaptive immune response to HPV