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Abstract
The effect of immunization protocol against S. mansoni infection with purified antigens from E. liei on resistance to S. mansoni infection and associated immunoparasitological changes in murine experimental model was studied. High significant reduction in worm burden, hepatic and intestinal tissue egg loads were observed on comparing the immunized groups with the infected control group (P > 0.001). The results showed an alteration in the Egg deposition, reduction in MGN, MGD amount of hepatic fibrosis, interference with granuloma maturation and cytokine secretion level. Results revealed that immunization with E. liei worm antigens stimulated IgG1, IgG2 and IgG4 secretion more than any other type of antigens. On the other hand, E. liei rediae antigens were more effective than other types in stimulating IgM secretion when compared to infected control group. In conclusion, our findings showed that multiple intraperitoneal adminestration of purified E. liei antigen induce highly significant reduction in worm burden, hepatic and intestinal tissue egg loads and granuloma size 8 weeks post infection