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Abstract
Aim: Tuberculosis is a dangerous disease and its death toll is increasing year by year. Intake of isoniazid and rifampicin might lead to fatal hepatorenal toxicity. The emerging field of stem cell therapy has raised great hope for improving the treatment of liver diseases. Results: The study revealed that serum liver enzymes activities, liver and kidney thiobarbituric acid reactive substance and nitric oxide levels, serum lipid profile and DNA fragmentation which exhibited by comet assay were significantly increased by isoniazid and rifampicin treatment associated with marked reduction of serum levels of albumin, total protein and albumin/globulin ratio, as well as liver and kidney glutathione levels and antioxidant enzymes activities, catalase and superoxide dismutase, as compared to normal controls. These results showed that N-acetyl cysteine, mesenchymal stem cells and white tea extract exerts their protective activity by different extents on liver and kidney by inhibiting the production of free radicals through induction of antioxidant enzymes and improving non-enzymatic thiol antioxidant, glutathione, and returning back the tested parameters towards near the normal controls. Furthermore, liver and kidney functions were improved greatly by mesenchymal stem cells followed by N- acetyl cysteine and white tea extract, respectively