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Abstract
Background: Psoriasis is a common chronic inflammatory skin condition that varies in severity; it affects 2{u2013}3% of the population. Visfatin a 52-kDa protein has been recently identified as an adipocytokine secreted primarily by visceral adipose tissue and various cells such as neutrophils, monocytes, macrophages, epithelial, endothelial cells and also present in the circulation in various inflammatory conditions. It is related to insulin resistance, obesity, atherosclerotic diseases and type II diabetes. Visfatin is assumed to be closely associated with the metabolic syndrome in addition to its role in inflammatory diseases, role in renal injury and in apoptosis. Objectives: The aim of the present study is to estimate visfatin levels in serum and tissue (lesional and non-lesional) of psoriatic patients and to correlate these levels with markers of the metabolic syndrome and disease severity