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Abstract
p27Kip1 is a member of a family of cyclin dependent kinase (CDK) inhibitors that bind to cyclin/CDK complexes and arrest cell division. There is considerable evidence that p27Kip1 plays an important role in multiple fundamental cellular processes, including cell proliferation, cell differentiation, and apoptosis. This study was performed to investigate the immunohistochemical expression of p27kip1in OSCC and to correlate this expression with different grades in order to evaluate its role in progression. Five , normal control cases where selected from paraffin blocks of mesenchymal where the normal surface epithelium was considered the normal control. Thirty cases of paraffin blocks were investigated in the study were 14 specimens well differentiated, 7 specimens moderately differentiated and 9 specimens were poorly differentiated OSCC