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Abstract
Non-Hodgkin lymphoma comprises a group of closely related yet heterogeneous diseases. There is evidence that genetic susceptibility plays a role in lymphomagenesis. The aim of the current study was to investigate the possible association between IL-2-330T/G and IL-10-1082A/G genetic polymorphisms and the susceptibility to B-cell Non-Hodgkin Lymphoma in a group of Egyptian patients. To achieve our aim, genotyping of the two genes was performed by PCR technique for 100 adult B-NHL patients and 100 age and gender matched healthy controls. The study revealed that the frequency of IL-2-330T/G polymorphic genotypes (TG & GG) was higher in B-NHL patients than controls (80% vs 58%) and conferred almost threefold increased risk of B-NHL in Egyptians (OR=2.90, 95%CI=1.54-5.44, p=0.001).