الفهرس 
Epidemiological Pattern of Infective Endocarditis at Cairo University Children’s Hospitals
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Abstract
Infective endocarditis (IE) is an infection of the endocardium and/or heart valves that involves vegetation, which may damage the endocardial tissue and/or valves. Up to date, no Egyptian published data regarding the epidemiologic findings of IE in children
Aim of the work: This study aimed to study the epidemiological pattern; mode of presentation, outcome of infective endocarditis at Cairo University Children’s Hospitals
Patients and Methods: This study was a cross-sectional study, conducted at Cairo University Children’s Hospital, Faculty of Medicine, Cairo University on 100 children admitted and diagnosed during the period from May 2018 to the end of December 2019.
Results: The age mean ± SD was 59.37±41.91 months and 63 cases (63%) were males. Fever was the most common clinical presentations (90%). Congenital heart disease, especially VSD, was present in most cases. Gram-positive organisms are the commonest pathogens among study populations. There was a statistically significant association between treatment responses after 2 weeks with age and weight as the p-value was 0.03, and 0.05, respectively. Also, there was a statistically significant association between CHD and the duration of treatment (p=0.03). Moreover, there was a statistically significant association between NICU admission and the type of antifungal treatment taken (p=0.04), types of organisms (p=0.02), and the presence of vegetations (p=0.02). A statistically significant association between types of organisms and the presence of vegetations and the size of vegetations was also recorded (p=0.02, p=0.047) respectively.
Conclusion: Congenital heart disease, especially VSD, is an increasingly significant risk factor for IE among Egyptian children. In addition, gram-positive organisms are the commonest pathogens among study populations.