الفهرس 
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Abstract
SUMMARY
The coronavirus disease 2019 (COVID-19) pandemic has rapidly spread across the globe, causing innumerable deaths and a massive economic catastrophe. Exposure to household members with confirmed COVID-19 is the most common source of infection among children. Children are just as likely as adults to get infected with SARS-CoV-2. Most children are asymptomatic and when symptoms occur, they are usually mild. However, children may be at a higher risk for severe or critical disease.
This study was conducted at Beni-Suef University Hospital to evaluate the association between COVID-19 infection and Multisystem Inflammatory Syndrome in Children (MIS-C). The mean age of the studied patients 52.5 ±54.9 months and most of them were males (62.5%). The average duration of hospital admission was 9.1±5.1 days.
Most of patients presented with more than one complaint. The main presentations of the affected children were DCL (27.5%), cough (22.5%), dyspnea and cyanosis (20.0%). Only (15.0%) of cases presented with fever.
As regards to the neurological manifestations among studied patients, our study showed that about 30 cases suffered from the presence of convulsions of different types. Also, Encephalopathy was common seen in 20 cases (51.3%). Headache was reported by six cases (15.4%), flaccid Paralysis was detected among only two cases (5.1%), and cerebellar ataxia was detected only among one case of the studied population.
Regarding the respiratory manifestations, the most common manifestations were cough (30.8%), dyspnea (28.2%) and cyanosis (35.9%). Mechanical ventilation was needed for 19 cases (48.7%).
Our study also investigated the cardiac manifestation among studied population and revealed that hypotensive shock was the most common manifestation in 12 (30.8%) cases and hypertension was among 6 (15.4%) cases. Tachycardia or bradycardia was detected among 5 (12.8%) cases of the studied population.
The study also found that GIT manifestations were frequent. Vomiting and diarrhea was the most common seen in 11 (27.5%) and 10 (25%) cases respectively. Abdominal pain was the complaint of 4 (10%) cases only. The effect of COVID-19 infection on kidney showed that 7 (17.9 %) cases had oliguria and oedema.
Other manifestations observed in patients were skin rash 12 (30.8%), non-purulent conjunctivitis 6 (15.4%) cases, and mucous membrane manifestations 12 (30.8%) cases of the studied population.
Among the children in the current study, 15 (39.5%) died, while 14 (37.8%) were discharged from the hospital without complications, and 9 other cases (23.7%) were discharged from the hospital with complications.