الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Occult HCV can be found in two different settings, one of these is (anti ̶ HCV +ve, serum HCV RNA - ve, normal liver function tests), the second is (anti ̶ HCV -ve, serum HCV RNA - ve, abnormal liver function tests of unknown etiology) Secondary OCI (residual infection continuing after spontaneous or therapy induced resolution of hepatitis C) Occult HCV is recognized by the presence of HCV-RNA in either circulating blood mononuclear cells, the liver, or concentrated plasma in the absence of detectable HCV-RNA in plasma.During the last years several direct acting antiviral agents (DAAs) have been licensed by most Western countries to be used mainly as part of IFN-free regimens offering high SVR rates (> 95%), short treatment duration and excellent safety profiles . In 2013 sofosbuvir was approved for use for HCV genotype 4 with pegylated interferon and ribavirin or with ribavirin alone (Hayashi et al., 2014).DAAs achieve a high sustained virologic response (SVR) which means undetectable HCV RNA 12 weeks (SVR12) or 24 weeks (SVR24) after treatment Completion, however occult HCV may be found in in either circulating blood mononuclear cells, the liver, or concentrated plasma.