الفهرس 
Vascular dysfunction in patients with pneumonia
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Abstract
Background: Community acquired pneumonia (CAP) is the most common cause of infant mortality worldwide, and one of the most common serious pediatric infectious diseases in developed countries. Recent studies documented a frequent association between CAP and the occurrence of acute cardiac complications. speckle tracking echocardiography (STE) is an advanced echocardiographic technique that allows quantification of myocardial deformation, called strain, using a semi-automated software, it provides additive information about cardiac function with an angle-independent segmental quantification of the movement of myocardial fibers for the identification of subtle myocardial damage, obtaining an early diagnosis of cardiac impairment.
Objectives: The aim of this study was to identify subclinical myocardial dysfunction in pneumonia patients in pediatric age by speckle tracking echocardiography and if the severity of myocardial involvement correlates with the severity of pneumonia.
Patients and Methods: This is a case-control cross sectional cohort study included pediatric patients diagnosed with pneumonia admitted at children Hospital, Faculty of Medicine, Cairo University. It includes 60 children, 30 cases of them were diagnosed with pneumonia and compared to 30 healthy controls.
Results: Our study showed that, there were statistically significant differences of echocardiographic parameters between the cases and control groups regarding left ventricular early mitral inflow velocity and mitral annular early diastolic velocity (LV E/E`), left ventricular end diastolic volume (LV EDV), global longitudinal strain (GLS), Aortic strain and left ventricular inter ventricular septum thickness in diastole ( LV IVSd). There was negative correlation between pneumonia severity index (PSI) and GLS and aortic strain, There is also positive correlation between PSI and LV E/E`.
Conclusion: There is functional vascular impairment in patients with pneumonia, they have both left ventricular systolic and diastolic dysfunction together with left ventricular hypertrophy. The impairment of echocardiographic parameters was correlated with severity of pneumonia