الفهرس 
Bronchial AsthmaOnly 14 pages are availabe for public view
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Abstract
Abstract:
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the second-most frequent drug type to cause hypersensitivity reactions. Asthma is one of the risk factors for NSAID hypersensitivity (NSAID-H) in adult patients.
Objective: To assess the frequency of confirmed NSAID-H and to evaluate its classification in adolescents and adults with asthma.
Subjects and Methods: This cross-sectional study was conducted on 100 Egyptian asthmatic patients who had a history of suspected reaction to NSAIDs, They were recruited from the allergy and immunology outpatient clinic and inpatient department at Ain Shams University Hospitals from 2020 and 2022. Cases between 10 and 60 years of age on inhaled corticosteroids or other controller medications were enrolled and subjected to full detailed clinical history and physical examination. According to the Global Initiative for Asthma: Global Strategy for Asthma Management and Prevention criteria, the levels of asthma symptom control and severity were recorded. The initial drug allergy workup was started with the stan¬dardized European Network of Drug Allergy question¬naire on drug allergy. Assessment of body mass index, chest x ray, skin prick test with Aspirin and a panel of common allergens, intradermal test with aspirin, and an oral provocation test with aspirin, complete blood picture with differential showing absolute eosinophil count, serum total Ig E and pulmonary function tests were performed.
Results: The frequency of confirmed NSAID-H was 19% in asthmatic patients who had a history of suspected reaction to NSAIDs, NSAID-H was found more frequently in patients born in Cairo and had allergic rhinitis, nasal polyps, history of previous reaction to NSAIDS and increased asthma severity. In addition, NSAIDs hypersensitivity patients had significant lymphopenia than others.
Conclusion: Patients with asthma are more liable to NSAIDs hypersensitivity and should be evaluated for reac¬tions to NSAIDs.