الفهرس | Only 14 pages are availabe for public view |
Abstract lorectal cancer (CRC) is already the third leading cause of cancer death in the world, and its incidence is steadily rising in developing nations (Ferlay et al., 2018). According to GLOBOCAN 2020, more than 1.9 million new cases of colorectal cancer (1,148,515 of the new cases are colon cancer with 6% percent of total new cases) and more than 930 000 deaths due to colorectal cancer (576,858 due to colon cancer) were estimated worldwide. Large geographical variations in incidence and mortality rates were observed. The incidence rates were highest in Europe and Australia and New Zealand, and the mortality rates were highest in Eastern Europe (Ferlay et al., 2022). Colorectal cancer is the third in incidence, but second in mortality. Incidence rates are approximately 4-fold higher in developed countries compared with developing countries, but there is less variation in the mortality rates because of higher fatality in developing countries. There is an approximately 9- fold variation in colon cancer incidence rates by world regions, with the highest rates in European regions, Australia/ New Zealand, and Northern America, with Hungary and Norway ranking first in men and women, respectively. Colon cancer incidence tends to be low in most regions of Africa and in South Central Asia (Siegel et al., 2021). C |