الفهرس 
Evaluation of serum and tissue levels of il-35 in alopecia areata cross sectional analytic study
ContentsOnly 14 pages are availabe for public view
 |  | from | 121 |  |  |
| | | from | 121 | | |
Abstract
Background: There is compelling evidence that alopecia areata is caused by an autoimmune reaction. Interleukin 35 (IL35) belongs to the IL12 cytokine family, which is expressed in regulatory T (reg) cells and functions as an immunosuppressive cytokine. It is also involved in the etiology of various autoimmune and inflammatory diseases.
Objectives: This study aims to measure serum and tissue biopsy IL35 in AA patients and compare it to healthy subjects.
Methods: This study included 40 AA patients and 40 healthy controls. Scalp involvement was assessed using the alopecia tool severity (SALT) to determine the clinical severity of the disease. Serum and tissue biopsy IL35 was measured using ELISA.
Results: Tissue and serum IL35 levels in patients with alopecia areata were significantly lower than controls (P <0.001 and 0.001 respectively). There was a weak positivecorrelation between duration and SALT score (p = 0.05, r = 0.296). However, there was no significant correlation between biopsy IL35, serum, age, and gender. Furthermore, no association was found between IL35 and age in either group, suggesting that age does not appear to affect IL35 levels under normal conditions.
Conclusions:IL35 may be involved in the cause of AA. The fact that both serum and tissue levels of IL35 were significantly lower than those of the control clearly showed that IL35 increased Treg cell proliferation and silencing activity while reducing Th17 cell differentiation and function