الفهرس 
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Abstract
Summary
Diseases which cause Respiratory distress occurs almost exclusively in premature infants.The incidence and severity of diseases that cause respiratory distress are related inversely tothe gestational age of the newborn infant. Approximately 2–3% of infants developrespiratorydistresssoonafterbirth.
Thrombocytopeniathatpresentsinthefirst72hoflifeusuallydevelopssecondaryto chronic fetal hypoxia. Platelets contribute to the basal barrier integrity of thealveolarcapillaries,whichselectivelyrestrictsthetransferofwater,proteins,andredbloodcellsoutofthevesselsandreducelungfluidaccumulationandlungedema.
Platelet has an important role in initiating the thrombotic event, but plateletcount alone does not give a complete picture of platelet maturity and its function.Plateletindicessuchasmeanplateletvolume(MPV),plateletcrit(PCT),andplateletdistribution width (PDW) areutilizedforthispurpose.
Plateletcrit(PCT)providesmorecomprehensiveinformationaboutthetotalthrombocytemass.Itissimilartotheredcellhaematocritandindicatesthepercentageofthe bloodproducedbythe platelets
Aimofwork
The aim of work of the current study, was to identify the value of plateletcrit(PCT) with the outcome of neonates withrespiratorydisorders.
To elucidate this aim, 120 neonates were included in the study and divided in to 60Neonatessufferingfromvarioustypesofrespiratorydiseasesand60healthyneonatesas the controlgroup.
Results:
Themeanageincasegroupwas6.11±3.03days,inthecontrolwas4.95±2.30days, with no significant difference in between. There was male predominance inboth groups58.3%incasegroup,51.7%incontrolgroup
Inthecurrentstudy,the number of WBCs in the case group on admission is higher than that of the number of WBC in the control group with Highly Significant P-value (0.003). The numberofLYM% was also higher in the case group on admission than in the control group. The number of PCTincasesthanincasegroup on admission was also higher than the control group. The numberofPlateletincases on admission was lower in casesthanincontrolgroup. After reducing the level of respiratory support,therewashighsignificantincreaseofWBCincasegroupthan in control,highsignificantdecreaseofLYM%,incasesthanincontrolgroup.
The number of hemoglobin in cases after reducing the level of respiratory support was lower than that of the cases on admission and also lower than that of the control group.
AsregardtoPCTatfirstday,therewasasignificantpositiverelationinbetweenPCTat firstdayand eachof Platelet andLengthofstay. There was also a significant positive correlation between the PCT and days of respiratory support. After reducing the level of respiratory support, there was a significant positive relation in between PCT andeachofLengthofstay,Gestationalage,PDW.
Conclusion:
Because neonates with respiratory disorders tend to have lower platelet counts and higher PCT values than those who are pathologically free, platelet count and PCT are likely related to the severity of the disease.PCT level in neonates with respiratory disorders is a significant predictor of poor outcome. As a result, monitoring PCT level offers a fresh approach to more aggressive treatments for high-risk groups and also serveas a marker for early assessment and prognosis of newborns with respiratory disorders.No neonate died during this study; all were released once they recovered.
Recommendations:
More investigation is required to fully comprehend the nature of the PCT level role in the prognosis prediction of neonatal respiratory distress disorders. More study is needed to understand the predictive values of PCT in neonates with sepsis.