الفهرس 
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Abstract
Coronary artery disease (CAD) is the leading cause of death in men and women. Regardless of declines in developed countries, both CAD mortality and the prevalence of CAD risk factors continue to rise rapidly in developing countries.
Hypertension, diabetes mellitus and Cigarette smoking have been reported to be risk factors of CAD and stroke through many studies, respectively.
Elevated levels of total- and low density lipoprotein cholesterol (TC and LDL-C), elevated levels of triglyceriges (TG) and low levels of high density lipoprotein cholesterol (HDL-C) are important risk factors for CAD.
Dyslipidemia has been identified as one of most important modifiable risk factor for CAD. Treating dyslipidemia has clear benefits in the primary and secondary prevention of coronary heart disease (CHD) in both sexes. This study focused on dyslipidemia as a risk factor of acute coronary syndrome (ACS).
we aimed to analyze lipid profile in patients with ACS who presents at sohag university hospital, and its clinical and complications pattern.
This study involved 100 patients with acute coronary syndrome and conducted in the Coronary Care Unit of Internal Medicine Department at Sohag University Hospital
All patients subjected to full history taking, clinical assessment and laboratory investigation which included Lipid profile [total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) and triglycerides (TG)] and 12 leads ECGs.
Our results showed that:
By comparing STEMI and NSTE-ACS groups regarding lipid profile the results revealed that: Regarding total cholesterol levels, there was a statistically significant elevation in total cholesterol in STEMI group compared to NSTE-ACS group (p=0.046). There was a statistically significant elevation in LDL-c in STEMI group compared to NSTE-ACS group (p=0.005). There was a statistically significant elevation in VLDL-c in STEMI group compared to NSTE-ACS group (p=0.033). There was a statistically significant decrease in HDL in STEMI group compared to NSTE- ACS group (p=0.003). There was a statistically significant elevation in Triglycerides in STEMI group compared to NSTE-ACS group (p=0.006). Also, there was a statistically significant elevation in TC/HDL and TG/HDL in STEMI group compared to NSTE-ACS group (p=0.008 & <0.001).
By comparing STEMI and NSTE-ACS groups regarding lipid profile the results revealed that Regarding total cholesterol levels, there was a statistically significant difference in total cholesterol, LDL-c, HDL, triglycerides, TC/HDL and TG/HDL in the three groups. There was no statistically significant difference in VLDL-c in the three groups (p>0.05).
The current study also revealed that there was significant relation between age groups and total cholesterol (P<0.001), LDL-c (P=0.009), VLDL (P=0.016), HDL (P=0.001), Triglycerides (P=0.008), TC/HDL (P<0.001) and
TG/HDL (P=0.040). Furthermore, there was no significant relation between gender and total cholesterol, LDL-c, VLDL, HDL, Triglycerides, TC/HDL and TG/HDL (P>0.05).
Finally, on comparison of complications between the STEMI and NSTE-ACS group groups, there was a statistically significant difference in complications. Similarly, on comparison of complications between the STEMI, NSTEMI and UA groups, there was a statistically significant difference in complications.
Conclusion
In conclusion, dyslipidemia was a highly prevalent risk factor in patients with ACS. There is a lower prevalence of high LDL-C and high TC and a high prevalence of high TG and lower HDL-C levels among the studied ACS patients. We also found that dyslipidemia was significantly correlated with age and non-significantly with sex. Further studies with larger sample size to confirm the current results, and to find out the infrequent risk factors of ACS.