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Abstract
Background : Valvular calcification is considered a manifestation of atherosclerosis, particularly aortic valve calcification and mitral annular calcification are reported to be associated with cardiovascular risk factors. The independent predictive value of valvular calcification for atherosclerotic CAD is not well-established.Objective: Evaluation of aortic valve calcification(AVC)and mitral annular calcification (MAC) as a predictor of development of atherosclerotic CAD using MSCT coronary angiography. Methods: Two groups ; each containing 100patients, first group with left sided valvular calcification , second group with no left sided valvular were subjected to non-contrast CT examination to calculate AVC,MAC and CAC using Agatston method followed by MSCT coronary angiography. Obstructive coronary artery disease was defined as >50%diameter stenosis Results: The mean age of the study population was (52.53_+11), 55% were males AVC was more prevalent than MAC. We found that there was significant relation between hypertension, Diabetes mellitus, dyslipidemia among left sided valvular calcification. One hundred twenty eight of patients had coronary artery disease, using chi square we found that there was significant relation between left sided valvular calcification and atherosclerotic CAD &it was considered as one of the independent predictors of CAD,( p value<0.005). CAC was found in 83.5% out of the subjects, linear regression analysis was done & we found that it was the only predictor of obstructive coronary artery disease.Conclusion: left sided valvular calcification had significant relation between atherosclerotic CAD but was not found to be one of the independent predictors of obstructive CAD