الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Genetic profiling of the leaves, as well as, botanical study including macroand micro-morphological studies of the different organs of Scaevola taccada (Gaertn.) Roxb. were achieved for identification and authentication of the plant. The ethanolic extract of the leaves was found to be safe and non-toxic up to 2g/Kg of body weight. The ethanolic extract and its fractions were subjected to different biological assays viz. anti-inflammatory, antihyperglycemic, antimicrobial, cytotoxic and anti-oxidant. The anti-inflammatory and antihyperglycemic activities were examined by in-vivo assays (STZ-induced diabetic rats model and carrageenan induced paw oedema model, respectively) where, the ethanolic extract of the leaves showed both antihyperglycemic and anti-inflammatory activities while the aqueous extract exhibited antihyperglycemic activity. For in-vitro biological activities, n-butanol fraction showed significant antifungal and antibacterial activity, in addition to its cytotoxic activity against HCT (colon carcinoma cell line ) while petroleum ether fraction showed cytotoxic activity against MCF-7 (breast carcinoma cell line) , moderate antifungal and antimicrobial activities against Gram negative bacteria. Ethyl acetate fraction exhibited antioxidant in DPPH assay and moderate antifungal activities. Quantitative estimation of the total phenolic and total flavonoid content of the leaves also evaluated. Preliminary phytochemical screening, proximate analysis, investigation of the lipoidal content, in addition to phytochemical investigation of the active fractions followed by isolation afford 8 compounds : Ü-amyrin , Ü-amyrin palmitate, Ü-amyrin acetate, stigmasterol and n-tetradecane from petroleum ether; Luteolin-7-O-Ý-glucoside from ethyl acetate , rutin and alidyjosioside from n-butanol