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Abstract Background: Secondary upper limb lymphedema is a chronic disease that affects patient’s quality of life or even a life threatening case. Propose of the study: to investigate the effectiveness of diode cluster laser (DCL) versus complete decongestive therapy (CDT) in the treatment of secondary post mastectomy lymphedema. Methods: 45 female patients with upper limb lymphedema (stage II, according to Foldi classification) were included in current study, their age ranged from 40 to 60 years. They were divided randamly into 3 groups 15 patients for each group. Procedures: Study group A (n=15) received DCL with conventional traditional program of physical therapy including; cryotherapy, manual massage, and range of motion exercise. Study group B (n=15) received CDT including manual lymph drainage, short stretch bandage, free active exercises and skin care program with the conventional traditional program. Control group C (n=15) received the conventional traditional program only. Treatment program was given with the frequency of 3 sessions per week for 2 months. The measurements of the upper limb were done by round measurements with tape at three points; wrist joint, elbow joint and at the end of the arm just below the axillary fold and water displacement by the volumetry were taken before, at the mid (after a month) and at the end of treatment (2 months). Results: Comparison between groups A and B revealed a significant difference of tape measurement at wrist (P=0.014), a significant difference between groups B and C (P=0.001), and no significant difference between A and C P=0.154 |