Search In this Thesis
   Search In this Thesis  
العنوان
Synthesis and evaluation of certain diaryl substituted heterocyclic compounds as potential anticancer agents /
الناشر
Soha Hussein Emam Mabrouk ,
المؤلف
Soha Hussein Emam Mabrouk
هيئة الاعداد
باحث / Soha Hussein Emam Mabrouk
مشرف / Salwa EL-Sayed Mohamed EL-Meligie
مشرف / Nadia Abdalla Khalil
مشرف / Eman Mohamed Ahmed
مشرف / Sawsan Abo-Bakr Zaitone
تاريخ النشر
2016
عدد الصفحات
06 P. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الصيدلة
تاريخ الإجازة
23/8/2016
مكان الإجازة
جامعة القاهرة - كلية الصيدلة - Pharmaceutical Sciences
الفهرس
Only 14 pages are availabe for public view

from 232

from 232

Abstract

This thesis comprises five chapters. The first one is an introduction which includes a brief literature survey on the synthesis, anticancer and antimitotic activities of 2-pyrazolines, 1,3,4-oxadiazoles and pyridines. The second chapter clarifies the aim of the work and the schemes adopted for the preparation of the target compounds. The third chapter deals with the theoretical discussion of the experimental work. The fourth chapter consists of the experimental part of the thesis which contains detailed procedures used for the synthesis of the target compounds, as well as the physical properties and detailed data obtained from elemental and spectral analyses. The fifth chapter includes discussion of the anticancer results compared to standard antimitotic agent colchicine, as well as a brief account on the results of the docking study and the correlation between these results and anticancer activity. It also includes the procedures of anticancer testing as well as the docking steps followed