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Abstract The aim of this study was to find out the effect of high intensity interval training on adiponectin hormone, fasting plasma glucose (FPG) and body mass index in women with diabesity. Forty diabetec obese women participated in the study, They were selected from Helwan General Hospital, they came for the obesity clinic, their ages ranged from 40-50 years and their BMI ranged from 30-34.9 kg/m2. They were divided into two groups equal (in number) with no significant difference between the two groups at the start of researsh. group A (study group): This group received low-calorie diet (1200 Kcal/ day) and high intensity interval training sessions for 3 sessions per week for twelve weeks. group B (control group): This group received low-calorie diet (1200 Kcal/ day) only for twelve weeks. The study was performed from (August 2015 to April 2016). The BMI, Adiponectin hormone and fasting blood glucose were measured before and after the program .The results of this study showed significant improvement for group (A) and (B) in adiponectin (54.97% {u2191}, 20.27% {u2191}), BMI (11.2% {u2193}, 6.3% {u2193}), FPG (19.95% {u2193}, 12.64% {u2193}) respectively. All of These findings suggest that High Intensity Interval Training is an effective tool to decrease insulin resistance and BMI and this effect may be mediated, in part, by the increase in adiponectin hormone. All findings represent the effective role of exercise to increase the adiponectin hormone in women with diabesity wich consequently helps in the treatment of diabesity |