الفهرس 
Analytical studies of imidapril hydrochloride, moexipril hydrochloride and hydrochlorothiazide Anti-hypertensive drugs
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Abstract
The study described in this thesis comprises four main parts: Part 1: In this part IMD and MOE drugs were investigated using thermal analysis (TA) measurements (TG-DTA) in comparison with electron impact (EI) mass spectral (MS) fragmentation at 70 eV. The behavior of the drug under TA decomposition revealed a moderate stability up to 180 and 155 oC for IMD and MOE, respectively, before a complete decomposition in the range 180-1000 oC and 155-800 oC. The initial decomposition was due to C2H6O2 and HCl loss, followed by C11H13N3O4 loss for IMD drug, and H2O, HCl followed by C16H21NO4 loss for MOE drug. This was the best-selected pathway comparable with decomposition using TA. Part 2: In this part aqueous alkaline degradation study was performed for imidapril hydrochloride (IMD) drug. Isocratic stability indicating the use of high-performance liquid chromatography (HPLC) was presented for the determination of IMD drug in the presence of its degradation products. The separations were performed using ACE generix 5C8 column and a mobile phase consisting of buffer (0.1 mol L-1 potassium dihydrogen phosphate, 0.02 mol L-1 tetra n-butyl ammonium hydrogen sulphate of pH=4.5 with 1N NaOH) and acetonitrile 60:40 (v/v) and ultraviolet detection at 210 nm. The method showed high sensitivity concerning linearity, accuracy, and precision over the range from 0.1 to 100 æg mL-1. The proposed method was used to determine the drug in its pharmaceutical formulation and to investigate the degradation kinetics of the drug{u2019}s alkaline-stressed sample. The reactions were found to follow a first-order reaction. The activation energy could also be estimated. International Conference on Harmonization guidelines (ICH) were adopted for method validation