الفهرس 
PUVA induced PLC-Like lesions in patients with mycosis fungoides :A clinical, pathological and immunohistochemical study
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Abstract
Background: The nature of pityriasis lichenoides chronica ( PLC) like lesions arising in mycosis fungoides ( MF) patients during treatment with PUVA is not fully understood. PLC like lesions has been observed in MF patients during treatment with PUVA. It has been of interest whether PLC like lesions is upgrading or downgrading of the disease. Objective: Is to investigate the nature of PLC-like lesions arising in MF patients receiving PUVA therapy both clinically, pathologically and immunohistochemically and to compare them with classic PLC lesions . Methods: The study included 15 MF patients who developed PLC like lesions during treatment with PUVA (group A) and 15 patients with classic PLC (group B) were included and served as controls. Thorough clinical examination was done for each patient. A 5mm punch biopsy was obtained and examined histopathologically and immunohistochemically. Results: In the present study no statistically significant difference was noted between group A and group B on the histopathological and immunohistochemical aspects ( P > 0.05) . A statistically significant difference was noted between group A and group B as regards age (P < 0.00001), Onset ( P= 0.003) and duration of the disease ( P < 0.00001), There was no statistically significant difference as regards course . In group A there was a significant correlation between extent of PLC like lesions and duration (P < 0.05). The extent of PLC like lesions showed non significant correlations with stage of MF, number of PUVA sessions received at time of its appearance, status of MF ( clinically improved or showed persistent lesions) and with cumulative dose of PUVA at time of its appearance (P > 0.05)