الفهرس 
Detection of prolonged QT interval among sickle cell diseased children
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Abstract
Prolonged corrected QT interval (QTc) is not uncommon among patients with sickle cell disease (SCD). We aimed at detection of cases of SCD with prolonged QTc, correlate QTc with estimated systolic pulmonary artery pressure (ESPAP), serum ferritin and other echocardiographic dimensions. This is a cross sectional descriptive study that included 46 SCD patients attending the hematology clinic at the new Children{u2019}s hospital, Faculty of medicine, Cairo university during the period of March 2014 to October 2015. Cases were subjected to full history, clinical examination and laboratory investigations in addition to 12 leads ECG and transthoracic color Doppler echocardiography. The mean age of the patients was 8.93 ± 5.26 years. Prolonged QTc interval was detected in19.57% with normal QT dispersion and no significant arrhythmias. Pulmonary hypertension was detected in 13.04%. There was no significant correlation between ESPAP and QTc (P=0.990, r=0.002). There was a significant positive correlation between QT dispersion and diameter of interventricular septum (IVS) (P=0.017, r=0.350). Also there was a significant weak positive correlation between QTc and the diameter of left atrium (LA) (P=0.047, r=0.295). The left ventricular end diastolic diameter (LVIDd) correlated significantly with serum ferritin (P=0.44, r=0.301). Prolonged QTc interval (>440 msec.) was detected in 19.57% of SCD cases. This increases the risk of arrhythmias that could be fatal and might necessitate beta blocker management. Pulmonary hypertension ({u2265}36 mmHg) was not a relatively common complication among patients with SCD in this study. It was detected in 13% of patients