الفهرس 
Association of macrophage migration inhibitory factor gene polymorphisms with Behcet’s disease in Egyptian patients
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Abstract
Macrophage migration inhibitory factor (MIF) gene is differentially expressed in many autoimmune diseases. A considerable evidence suggests that MIF may be involved in the pathogenesis of many inflammatory diseases. The purpose of this work is to measure the polymorphisms in MIF gene in Behcet{u2019}s disease and to correlate these polymorphisms with the disease activity and some clinical findings in BD. The polymorphisms in the MIF gene were measured by restriction fragment length polymorphism (RFLP) technique. This was assessed in 50 Behcet{u2019}s patients and 50 normal control subjects. No statistically significant differences were found between patients group and control group regarding MIF gene polymorphisms in both rs755622 and rs2096525 with p-value 0.663 and 0.564 respectively. Also, both cases and controls were subjected to analysis of dual mutation of the two studied SNPs and non-statistically significant data was revealed (p=0.525), However posterior uveitis was significantly higher among patients with mutant genotype than patients with wild genotype (p=0.007) regarding rs2096525. The association between different genotypes of the two studied SNPs and the development of various clinical features of BD (oral ulcers, genital ulcers, skin manifestations, pathergy test and vascular involvement) was evaluated and no statistically significant difference was noticed between wild and mutant genotypes in the patient group (P>0{u2022}05). There was no statistically significant difference between patients with mutant genotype and patients with wild genotype regarding severity and activity