الفهرس 
Comparison of the effect of puva versus re-puva on the extent of oxidative dna damage in psoriatic patients
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Abstract
Photochemotherapy (PUVA) is one of the classic treatment modalities of psoriasis. Adding retinoids in the form of Re-PUVA is hypothesized to reduce the possible carcinogenic potential of PUVA. Aim of work: To evaluate the possible carcinogenic protective effect of adding retinoids to PUVA in psoriatic patients.Materials and Methods: A prospective, randomized, controlled study that included twenty patients with psoriasis who were then randomly divided into two groups; group A received PUVA therapy and group B received Re-PUVA therapy. Each of the 20 patients received 30 sessions of PUVA photochemotherapy. Patients from group B received additional oral retinoids two weeks prior to the start of session and until the end of the PUVA sessions. Serum samples were taken from each of the 20 patients, before and after the last PUVA session and were used to measure 8-oxoG level.Results: A significant DROP in the PASI score was detected in both. However, onset of clinical response was significantly earlier in the Re-PUVA group (P value = 0.037) together with significantly lower cumulative dose of UVA (P = 0.002).A rise of serum level of 8-oxoguanine level was noticed in psoriasis patients following PUVA therapy, Contrarily, a DROP of serum level of 8-oxoguanine was noticed following Re-PUVA therapy. Comparing the change of serum levels of 8-oxoguanine in patient receiving PUVA versus Re-PUVA showed more significant DROP of 8-oxo guanine in the patients receiving Re-PUVA (P=0.023). Conclusion: Re-PUVA was able to achieve the same clinical response as PUVA in psoriasis patients, but with an earlier onset of clinical response, less UVA cumulative dose, less DNA damage in the serum, and hence a less carcinogenic potential