الفهرس 
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Abstract
Ulcerative colitis (UC) is one of the two major forms of inflammatory bowel disease (IBD). It is a chronic relapsing inflammatory disorder affecting the gastrointestinal tract. The precise etiology is unknown, but it was hypothesized that it results from inappropriate immune response in genetically predisposed individual. It is a debilitating disease that leads to serious complications.Experimentally, dextran sodium sulphate (DSS)-induced ulcerative colitis (UC) is an excellent model mimicking human affection. Therefore, it helps to analyze disease etiology and pathogenesis and provides a good opportunity to study both acute and chronic UC by changing the concentration and duration of DSS administration.Several biochemical and clinical studies were focused on the application of Au NPs as a therapeutic modality in several diseases such as rheumatoid arthritis, liver fibrosis, diabetes mellitus and chronic myeloid leukemia. Further studies are required to establish Au NPs as a new therapeutic agent in UC.Therefore, the present study aimed to investigate the therapeutic potential of Au NPs in repairing the histological and biochemical alterations induced by DSS in the colon of adult mice.For this purpose, forty eight adult mice were used divided into three groups. group I (control group): included twenty four mice equally subdivided into two subgroups (twelve mice each): subgroup Ia: was kept without treatment, subgroup Ib: received Au NPs at a dose of 2.5 mg/kg.b.wt/day through intra peritonial injection for 2 weeks started at day 14. group II (DSS-group): included twelve mice, in which chronic colitis was induced by supplementing their drinking water with 3% DSS (molecular weight 40,000 Da). It was given in a cyclic manner, consisting of three cycles; 4 days /cycle of DSS and drinking normal water for 6 days. group III (DSS+ Au .