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العنوان
Evaluation of bone mineral density in children with Coeliac disease in Minia Governorate /
المؤلف
Mohammed, Aya Mahmoud Amer.
هيئة الاعداد
مشرف / اية محمود عامر محمد
مشرف / مصطفي أحمد الفولي
مشرف / محمد فؤاد عبدالباقي علام
مشرف / يسرا سمير فضل
مناقش / عفاف عبدالوهاب قراعة
مناقش / عبدالحكيم عبدالمحسن
الموضوع
Bones - Metabolism - Disorders. Mineral metabolism - Disorders. Celiac disease.
تاريخ النشر
2023.
عدد الصفحات
102 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
طب الأطفال ، الفترة المحيطة بالولادة وصحة الطفل
تاريخ الإجازة
5/1/2023
مكان الإجازة
جامعة المنيا - كلية الطب - طب الأطفال
الفهرس
Only 14 pages are availabe for public view

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Abstract

Objective, research-based grading of CD severity is possible with duodenal biopsies and serology.
Among the long-term problems that may arise from Crohn’s disease include osteoporosis, anaemia, and even intestinal cancer, since it is a multi-systemic sickness that may affect several organs.
In Egypt, the rate of CD is said to be between 0.5 and 0.6 percent, which is lower than the projected global rate of 1 percent.
In most instances, symptoms improve when on a gluten-free diet but return when gluten is consumed again.
The purpose of this research is to use a DEXA scan to evaluate bone mineral density in children who have celiac disease.
Bone mineral density below the age-appropriate range corresponds to a Z-score of 2.
Definitions of osteopenia and osteoporosis are not applied to bone mineral density (BMD) readings in younger populations.

Our cross-sectional research recruited kids and teens between the ages of 5 and 18 who were already diagnosed with Coeliac disease and were being seen at the paediatric outpatient clinic at Minia University’s Maternity and Children’s Hospital.
The research was carried out during the months of July 2021 and January 2022.
Eighty youngsters were enrolled in the research and split into two groups:
group 1 consisted of 40 kids with a diagnosis of coeliac disease or a diagnosis of both celiac disease and diabetes.
The second group, a control group consisting of forty kids who all look great, is the healthy kids.
Our primary finding was that in both the case and control groups, women made up the majority (26% vs. 24%) of participants.
Furthermore, results indicated that 60% of afflicted children had heights below the 3rd percentile and BMIs below the 60th percentile for their ages and sexes.
DEXA scan, Calcium, and vitamin D3 levels were significantly higher in patients compared to controls.
Long-term celiac disease was also positively correlated with bone mineral density (BMD) as measured by DEXA.
Results from Alkaline Phosphatase and DEXA scans were also significantly related to vitamin D levels.
In our research, we found that 100% of cases had positive results for both the 1st anti TTG IgA and biopsy. However, only 35% of patients had excellent disease control, while 65% had poor control.

Conclusion
Bone density in children and adolescents is negatively affected by poorly managed Coeliac disease, which may cause a number of difficulties in everyday life owing to the need for particular dietary restrictions and/or formula.