الفهرس 
Management of Non Muscle Invasive Urothelial Bladder CancerOnly 14 pages are availabe for public view
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Abstract
This study was a prospective randomized controlled study to evaluate the effect of Neoadjuvant Chemotherapy before radical cystectomy versus radical cystectomy alone as a treatment for muscle invasive bladder cancer regarding surgical efficacy, Pathologic response and peri-operative morbidity.
The study included 40 patients with non-metastatic muscle-invasive bladder cancer (T2–T4a) urothelial bladder cancer, Patients staged with non-metastatic muscle-invasive bladder cancer (T2–T4a) as proved by pathological examination after transurethral resection of a bladder tumor using the Tumour, Node, Metastasis (TNM) Classification.
After definitive treatment of the patients overall short- term complications after radical cystectomy, length of stay, readmission rate and time to last follow-up and/or death. Moreover, wound, lymphatic, gastrointestinal, hematological, pulmonary, cardiovascular and genitourinary complications were compared using a dichotomization of the Clavien–Dindo classification (CDC) with no significant difference between two group.
Pathological T- and N-stage outcome of Cystectomy specimens was examined and the rate and degree of tumor down staging was determined and compared for patients of both groups.
We found that there was no statistically significant difference between the two groups regarding duration of surgery, and lymph node dissection, but there was highly statistically significant difference between the two groups regarding Blood loss (ml) and Length of stay (Da ) which was more in group1.
Regarding Pathological down staging postoperative, there was statistically significant more in group 2 compared to group 1. And there was no statistically significant difference found between two groups regarding lymph nodes.